Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer’s disease

Authors: I-Hsuan Yang, Che-Yung Kuan, Sheng-Long Zhang, Zhi-Yu Chen, Chi-Han Li, Ya-Jyun Liang, Wei-Ting Kuo, Chia-Ting Chang, Jason Lin, Hsing-Pang Hsieh, Jang-Yang Chang, Feng-Huei Lin

https://doi.org/10.1016/j.eurpolymj.2024.113151, 2024

Published in: European polymer journal

Tags: Alzheimer’s disease; Cathepsin S; Amyloid-β peptides; PLGA-PEG; Hydroxyapatite; endocytosis