PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis

Authors: Weilong Hong, Xue Zeng, Houping Wang, Xuxin Tan, Yu Tian, Hongtao Hu, Milad Ashrafizadeh, Gautam Sethi, He Huang, Chenyang Duan

https://doi.org/10.1016/j.phrs.2024.107228, 2024

Published in: Pharmacological research

Tags: PGC-1α, LDHB, Mitochondrial quality control, APAP, Acute liver injury