The phosphatase PPM1F, a negative regulator of integrin activity, is essential for embryonic development and controls tumor cell invasion

Authors: Tanja M. Grimm, Nina I. Dierdorf, Marleen Herbinger, Sarah Baumgärtner, Erik Sontowski, Christoph Paone, Timo Baade, Christof R. Hauck

https://doi.org/10.1186/s12915-025-02254-3, 2025

Published in: BMC Biology

Tags: Cell adhesion; filamin A; integrin activity; protein phosphatase; PPM1F; talin; threonine phosphorylation; knock-out mouse; developmental defects; cancer cell invasion