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Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration

Jun 13, 2024

Authors: Fang Yu, Satanay Hubrack, Christophe M. Raynaud, Asha Elmi, Rafah Mackeh, Nourhen Agrebi, Gaurav Thareja, Abdelaziz Belkadi, PhD, Hesham Al Saloos, Ayeda Abdulsalam Ahmed, Saleema C. Purayil, Yasmin A. Mohamoud, Karsten Suhre, Charbel Abi Khalil, Frank...

Differential effects of coverslip-induced hypoxia and cobalt chloride mimetic hypoxia on cellular stress, metabolism, and nuclear structure.

Jun 13, 2024

Authors: Florencia Lamela, Ronell Bologna-Molina, Felipe Parietti, Vanesa Pereira-Prado, Magdalena Millán, Alejandro Silva, Juan Llaguno, Julia Alonso, Ariel Fernández, José Sotelo-Silveira, Manoela Domingues, Miguel Arocena, Jimena Hochmann...

Human dendritic cell interactions with the zoonotic parasite Cryptosporidium parvum result in activation and maturation

Jun 13, 2024

Authors: Ralf Ross, Seyed Sajjad Hasheminasab, Ivan Conejeros,Ulrich Gärtner,Faustin Kamena, Andreas Krueger, Anja Taubert and Carlos Hermosilla https://doi.org/10.3389/fimmu.2024.1388366, 2024 Published in: Frontiers in Immunology Tags: Cryptosporidium parvum,...

Biological impact and therapeutic potential of a novel camptothecin derivative (FLQY2) in pancreatic cancer through inactivation of the PDK1/AKT/mTOR pathway

Jun 13, 2024

Authors: Wenchao Wang, Haonan Xiong, Lei Li, Xialin Hu, Wenya Zhuang, Jiangtao Li, Xuanrong Sun, Yanlei Yu, Yuanquan Yu, Yinghao Guo, Yihang Wang, Ruojiong Wang, Hong Wang, QingYong Li  https://doi.org/10.1016/j.bioorg.2024.107436, 2024 Published in: Bioorganic...

Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis

Jun 13, 2024

Authors: Julien Nadjar, Sylvain Monnier, Estelle Bastien, Anne- Laure Huber, Christiane Oddou, Léa Bardoulet, Hubert B. Leloup, Gabriel Ichim, Christophe Vanbelle, Bénédicte F. Py, Olivier Destaing, Virginie Petrilli https://doi.org/10.1126/scisignal.abn8003 , 2024...
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