Authors: Adrián Puerta; Aday González-Bakker; Guido Santos; José M. Padrón https://doi.org/10.3390/molecules27165261, 2022 Published in: Molecules Tags: phenotypic drug discovery; cancer; natural products; live cell imaging; machine learning; antimitotic drugs;...
The non-invasive nature of label-free imaging means cells can be continuously monitored, over infinite periods of time, which means kinetic EC50 values can also be calculated. Time-dependent EC50 values provide information about drug stability; whether a drug’s...
This Feature Application shows the huge potential that Nanolive imaging holds for the drug discovery process, where cytotoxicity remains one of the major causes of drug withdrawal, and there is an urgent need for reliable and time-saving assay workflows. Our first...
Authors: Nicholas J. Carruthers, Sharon A. McClellan, Mallika Somayajulu, Ahalya Pitchaikannu, Denise Bessert, Xudong Peng, Kylie Huitsing, Paul M. Stemmer and Linda D. Hazlett https://doi.org/10.3390/pathogens9090766, 2020 Published in: Pathogens Tags: Pseudomonas...
