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PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis

Jun 13, 2024

Authors: Weilong Hong, Xue Zeng, Houping Wang, Xuxin Tan, Yu Tian, Hongtao Hu, Milad Ashrafizadeh, Gautam Sethi, He Huang, Chenyang Duan https://doi.org/10.1016/j.phrs.2024.107228, 2024 Published in: Pharmacological research Tags: PGC-1α, LDHB, Mitochondrial quality...

Superior Drug Delivery Performance of Multifunctional Bilosomes: Innovative Strategy to Kill Skin Cancer Cells for Nanomedicine Application

Jun 13, 2024

Authors: Ewelina Waglewska, Julita Kulbacka & Urszula Bazylinska https://doi.org/10.2147/IJN.S450181, 2024 Published in: International Journal of Nanomedicine Tags: nanovesicular carriers, human melanoma, A375 cells, Me45 cells, antitumor activity,...

Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer’s disease

Jun 13, 2024

Authors: I-Hsuan Yang, Che-Yung Kuan, Sheng-Long Zhang, Zhi-Yu Chen, Chi-Han Li, Ya-Jyun Liang, Wei-Ting Kuo, Chia-Ting Chang, Jason Lin, Hsing-Pang Hsieh, Jang-Yang Chang, Feng-Huei Lin https://doi.org/10.1016/j.eurpolymj.2024.113151, 2024 Published in: European...

Modeling Absorption Dynamics of Differently Shaped Gold Glioblastoma and Colon Cells Based on Refractive Index Distribution in Holotomographic Imaging

Jun 13, 2024

Authors: Joanna Depciuch, Paweł Jakubczyk, Dorota Jakubczyk, Bartosz Klebowski, Justyna Miszczyk, Magdalena Parlinska-Wojtan https://doi.org/10.1002/smll.202400778 , 2024 Published in: Small Tags: gold nanoparticles, cytotoxicity, anti-cancer therapy,...

Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration

Jun 13, 2024

Authors: Fang Yu, Satanay Hubrack, Christophe M. Raynaud, Asha Elmi, Rafah Mackeh, Nourhen Agrebi, Gaurav Thareja, Abdelaziz Belkadi, PhD, Hesham Al Saloos, Ayeda Abdulsalam Ahmed, Saleema C. Purayil, Yasmin A. Mohamoud, Karsten Suhre, Charbel Abi Khalil, Frank...
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